From prague to Karlovy Vary?

I wonder if it is possible to go from Prague%26#39;s city center to Karlovy Vary by bus or train.Please give details(bus number,prices etc).And something else..is it cold there these days?Are warm clothes recommended?

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student agency goes from metro florenc or airport to karlovy vary, evry hour, from 50 - 130 czk.

www.studentagency.cz/mainpage.php…

or check idos.cz for other connections...

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